The Lancet reports that Naltrexone, commonly used to treat alcoholics and heroin addicts, and the anti-smoking drug bupropion led to greater weight loss than diet and exercise alone.
It is thought the treatment may help beat food cravings.
The treatment was not without side effects which included nausea, headaches, constipation, dizziness, vomiting and a dry mouth.
Professor Finer, an obesity expert from University College London, said combination treatments were likely to be the future for obesity drugs.
But he said he was not overly impressed with the weight loss seen in the trial, especially given the side-effects.
"The question will be can they define who the responders are and also can you get better results by combining the drug with a more effective weight loss programme," he said.
"We desperately need effective drugs but we have to have very high standards of safety and acceptability to patients."
With thanks to www.bbc.co.uk.
To read the full story go to:
http://www.bbc.co.uk/news/health-10802279
